Anti – Caries Vaccine

In a report on a preclinical investigation titled “Flagellin Enhances Saliva Ig A Response and Protection of Anti-caries DNA Vaccine,” lead author Wei Shi, Wuhan Institute of Virology, Chinese Academy of Sciences, and his team of researchers demonstrate that anti-caries DNA vaccines, including pGJA-P/VAX, are promising for preventing dental caries. Shi found that enhanced surface protein immunoglobulin A responses in saliva were associated with inhibition of S. mutans colonization of tooth surfaces and endowed better protection with significant less carious lesions. In conclusion, the study demonstrates that recombinant Salmonella could enhance specific immunoglobulin A responses in saliva and protective ability of pGJA-P/VAX, providing an effective mucosal adjuvant candidate for intranasal immunization of an anti-caries DNA vaccine. “These papers highlight the exciting potential of using vaccines to protect against dental caries,” said JDR Editor-in-Chief William Giannobile. “This research is promising and provides optimism to help promote public health of caries-susceptible individuals.”